DNA Renewal

DNA Renewal

Product type: ampoule firming serum
Format: 5 sealed ampoules × 5 ml (25 ml)
Course: 25–35 days (1 ampoule every 5–7 days)
Active ingredients: NAD+ (nicotinamide adenine dinucleotide), PDRN (polydeoxyribonucleotide from salmon DNA), peptide complex
Packaging: premium magnetic box, amber glass ampoules
Storage: in a cool, dry place, up to +25 °C, away from direct sunlight
Suitable for: all skin types, especially mature, tired skin that has lost firmness

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Contents

1. A serum that works at the cellular level
2. PDRN — DNA fragments that support skin renewal
3. NAD+ — energy for every cell
4. Peptide complex — the architecture of firmness
5. Why ampoules, not a bottle
6. Clinical research results
7. Ingredients
8. Who this serum is for
9. How to use
10. References

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1. A serum that works at the cellular level

We tend to think about skin from the outside: fine lines, pigmentation, tone. But the way skin ages really begins deeper down — in cells that gradually lose their ability to renew, to produce collagen and to protect themselves from everyday stress.

DNA Renewal is a new-generation ampoule serum designed to work exactly where those visible signs of ageing begin. Its three key actives — PDRN, NAD+ and a peptide complex — support three levels of skin renewal: cellular renewal, cellular energy and the collagen support structure.

In the world of Korean skincare, PDRN has been named ingredient of the year by Vogue, Stylevana and The Aesthetic Ascent [1]. NAD+ is being called "the new vitamin C" — a molecule that helps skin cells behave as they did when they were younger [2]. DNA Renewal by LONGIVIYA is one of the few products to bring both of these advanced actives together with peptides in a sealed ampoule format.

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2. PDRN — DNA fragments that support skin renewal

PDRN (polydeoxyribonucleotide) is made up of purified DNA fragments obtained from wild salmon. The ingredient was first developed in Italy in the 1990s for regenerative medicine — for wound healing and tissue recovery after surgery and burns [3].

In South Korea, PDRN became the basis of injectable biorevitalisation treatments — one of the most sought-after anti-age protocols in aesthetic-medicine clinics. A single session of PDRN mesotherapy in Bangkok costs 14,500–25,000 baht ($400–700) [4].

The breakthrough of recent years has been stabilising PDRN in topical (leave-on) formulas. Modern technology allows PDRN to reach the upper layers of the epidermis, where it supports key processes:

— Supports the skin's synthesis of type I and III collagen — the proteins behind firmness and elasticity — Engages the A2A purinergic receptors involved in skin renewal — Helps calm the look of sensitive, reactive skin — Supports the skin barrier's recovery after intensive treatments (peels, laser, microneedling)

The PDRN in DNA Renewal comes from wild salmon (salmon DNA) — a source with excellent biocompatibility with human skin cells.

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3. NAD+ — energy for every cell

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell of your body. It takes part in more than 500 enzymatic reactions and is essential to cellular respiration, DNA repair and protection from oxidative stress [5].

The catch is that skin's NAD+ levels fall with age, just as they do throughout the body. By the age of 50, cellular concentrations are around half of what they were at 20. This is one of the key reasons skin loses radiance, renews more slowly and shows the accumulated effects of UV exposure.

What NAD+ does when applied to the skin:

— Helps restore the energy potential of skin cells, so they renew more readily — Supports the skin's own renewal processes, helping cells cope with the visible effects of UV exposure — Improves the look of skin vitality — skin looks more alive, radiant and rested — Evens skin tone without harsh acids — NAD+ is called "the new vitamin C" for the gentle way it works on tone

An important detail: NAD+ is an unstable molecule that oxidises quickly on contact with air. That is exactly why we chose a sealed ampoule format — each ampoule is sealed separately and opened only just before use. In an ordinary dropper bottle, NAD+ loses its activity after just a few openings.

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4. Peptide complex — the architecture of firmness

Peptides are short chains of amino acids that act as signalling molecules for the skin. They "tell" cells what to do: build collagen, strengthen the barrier, ease expression lines.

The peptide complex in DNA Renewal complements the work of PDRN and NAD+:

— PDRN supports renewal at the cellular level — NAD+ gives cells the energy for that renewal — Peptides guide the process, giving cells specific tasks: "build collagen", "strengthen the barrier", "support the matrix"

Together, the three actives form a system: energy + instruction + building blocks. That is why the triple formula does more than any single ingredient on its own.

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5. Why ampoules, not a bottle

Most serums on the market come in dropper or pump bottles. That is convenient for everyday use, but hard on unstable actives.

Every time you open a bottle, the formula meets the air. NAD+ oxidises. Peptides degrade. By the end of the month you are applying a very different serum from the one you bought.

DNA Renewal comes in 5 sealed ampoules of 5 ml. Each ampoule lasts 5–7 days. You open a fresh ampoule and get a fresh, fully active formula. It is the same principle behind the professional meso-cocktails used in aesthetic-medicine clinics.

The ampoule format is not marketing. It is the only way to make sure NAD+ and peptides work from the first application to the last.

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6. Clinical research results

Focus	Study	Result
Skin renewal	PDRN in dermatology (literature review)	PDRN supports the synthesis of type I and III collagen, aids tissue recovery and reduces inflammation via A2A purinergic receptors [3]
Immunomodulation	Chen et al., 2023; RCT, healthy adults, 84 days	Beta-glucans from Ganoderma lucidum (a similar A2A-receptor mechanism) significantly raised immune response [6]
Cellular energy	NAD+ in cellular metabolism (review)	Declining NAD+ with age is a key mechanism of ageing; replenishing NAD+ restores cellular respiration and DNA repair [5]
Skin anti-ageing	Topical NAD+ and NMN (2025–2026, K-beauty formulas)	Topical NAD+ improves skin tone, speeds cell renewal and brightens without irritation [2]
Skin recovery	PDRN regenerative research (clinical experience)	In published research, PDRN has been studied for its role in supporting the skin's natural recovery [4]

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7. Ingredients

Active ingredients (per 5 ml ampoule):

Ingredient	INCI	Function
PDRN	Sodium DNA	Renewal, support for collagen synthesis
NAD+	Nicotinamide Adenine Dinucleotide	Cellular energy, DNA repair
Peptide complex	Peptide complex	Signalling support for collagen production

Supporting ingredients: hyaluronic acid, niacinamide, adenosine.

Format: 5 sealed ampoules × 5 ml, total volume 25 ml.

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8. Who this serum is for

— You are 35+ and noticing a loss of firmness, a softening jawline, skin that feels thinner and drier

— You want an at-home step for smoother, firmer, more hydrated-looking skin — no needles, no clinic visit, no downtime

— Your skin looks tired — a dull tone, lost radiance, a "tired face" even after a full night's sleep

— You have had laser treatments, peels or microneedling and want to support recovery

— You have already tried peptide or hyaluronic-acid serums and want the next level — active cosmeceuticals

— You are looking for a course-based routine with a proven formula, not "one more jar of cream"

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9. How to use

Evening routine (recommended):

1. Cleanse as usual
2. Apply toner
3. Open a DNA Renewal ampoule
4. Apply 3–5 drops to face, neck and décolleté with light pressing movements
5. Let it absorb (1–2 minutes)
6. Apply your moisturiser

One ampoule lasts 5–7 days. Keep the opened ampoule in the fridge.

Course: 5 ampoules = 25–35 days. For lasting results, repeat the course every 2–3 months.

Pairs well with: DNA Renewal is a perfect match for Youth Code (NMN + resveratrol + spermidine) — youth on the outside and within. The NAD+ in the serum and the NMN in Youth Code create synergy: NMN raises NAD+ levels systemically, while DNA Renewal delivers NAD+ directly to the skin's cells.

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10. References

[1] Vogue. 7 K-Beauty Trends Shaping 2026. Vogue, 2026.

[2] Korean Skincare Coach. Top Skincare Trends for 2026 and the Ingredients Driving the Shift. 2026.

[3] Squadrito F et al. Pharmacological Activity and Clinical Use of PDRN. Front Pharmacol. 2017;8:224.

[4] Aura Bangkok Clinic. Rejuran Injection in Bangkok — Clinical Overview. 2025.

[5] Verdin E. NAD+ in aging, metabolism, and neurodegeneration. Science. 2015;350(6265):1208-1213.

[6] Chen SN et al. Evaluation of Immune Modulation by β-1,3; 1,6 D-Glucan Derived from Ganoderma lucidum in Healthy Adult Volunteers, A Randomized Controlled Trial. Foods. 2023;12(3):659.

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Not a medicinal product. Cosmetic product for external use only. A patch test is recommended before use.