Box 04 · Slimness + Immunity (Reta 10 mg)

Box 04 · Slimness + Immunity (Reta 10 mg)

Formulation: Retatrutide 10 mg · Thymosin Alpha-1 10 mg · Glutathione 1500 mg · KPV 10 mg · BAC Water 3 ml × 4

Purity: ≥99.0% (HPLC)
Storage: −20 °C (before opening), +2…+8 °C (after reconstitution, no longer than 28 days)

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Contents

1. What this box is for
2. Retatrutide — triple metabolic agonist
3. Thymosin Alpha-1 — conductor of the immune system
4. Glutathione — the cell's master antioxidant
5. KPV — a peptide studied in the context of inflammation
6. How the components complement one another
7. Value in this box
8. References

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1. What this box is for

Any substantial change in the body places a load on the immune system. The scientific literature discusses how intensive metabolic processes may temporarily affect the immune response, raise oxidative stress, and activate inflammatory cascades.

This box is assembled for researchers interested in a measured approach: metabolic body-weight research (Retatrutide), reinforced by three peptides, each studied for the support of the body's defensive systems. Thymosin Alpha-1 is a modulator of the immune response. Glutathione provides antioxidant protection for cells. KPV is a modulator of inflammatory processes.

Three layers of protection while the body changes.

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2. Retatrutide — triple metabolic agonist

The next evolutionary step after tirzepatide. Retatrutide is a synthetic 39-amino-acid peptide that interacts simultaneously with three receptors: GLP-1, GIP, and the glucagon receptor (GCGR). Where tirzepatide engages two of the three, Retatrutide recruits all three — and it is the third, the glucagon receptor, that draws particular attention from researchers, since it is linked to energy expenditure and fat oxidation.

In the study by Jastreboff A.M. et al., published in The New England Journal of Medicine (2023), participants who received Retatrutide in a phase 2 trial showed body-weight reduction of up to 24.2% over 48 weeks. At the end of the study no plateau had been reached — the curve was still trending downward [1].

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3. Thymosin Alpha-1 — conductor of the immune system

One of the most extensively studied immune peptides in the world. Thymosin Alpha-1 is a 28-amino-acid peptide produced naturally by the thymus. The thymus is a central organ of the immune system that shrinks with age (thymic involution), and the production of Thymosin Alpha-1 declines along with it.

What sets this peptide apart is its ability not merely to stimulate immunity but to modulate it — to maintain the balance between activation and suppression of the immune response. In the scientific literature this is termed immunomodulation, as distinct from immunostimulation [2].

In studies by Garaci E. et al., an influence of Thymosin Alpha-1 on the maturation of dendritic cells and the activation of T-lymphocytes was noted. The peptide is registered as a medicinal agent in a number of countries for clinical use — one of the few peptides to hold such status [3].

Within this box, Thymosin Alpha-1 is studied as support for the immune system during a period of intensive metabolic change.

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4. Glutathione — the cell's master antioxidant

Glutathione (γ-glutamyl-cysteinyl-glycine) is a tripeptide produced in every cell of the body. Scientists call it the "master antioxidant": it not only neutralizes free radicals itself but also regenerates other antioxidants — vitamins C and E.

Endogenous glutathione synthesis declines with age. The scientific literature discusses the link between its falling levels and oxidative stress, which is regarded as one of the factors in cellular aging [4].

In the context of immunity, Glutathione plays a distinctive role: it is required for the normal functioning of immune cells and takes part in detoxification processes. The 1500 mg amount is among those most frequently seen in research protocols.

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5. KPV — a peptide studied in the context of inflammation

KPV is a fragment of the hormone α-MSH (amino acids 11–13) that draws researchers' attention for its ability to modulate inflammatory signals at the cellular level.

Inflammation is not only a symptom but also one of the mechanisms of the immune response. Chronic low-grade inflammation (inflammaging) is discussed in the scientific literature as a factor influencing immunity, gut condition, and overall health. KPV is studied as a potential modulator of the NF-κB pathway — a central regulator of the inflammatory cascade [5].

Within this box, KPV complements Thymosin Alpha-1: where Thymosin modulates the immune response at the level of T-cells, KPV is studied for modulation of the inflammatory background — the foundation on which the immune system operates.

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6. How the components complement one another

Four components — three layers of protection: immunity, antioxidants, inflammation.

Component	Research focus
Retatrutide 10 mg	Metabolic body-weight research (triple GLP-1/GIP/GCGR agonist)
Thymosin Alpha-1	Immunomodulation: T-cells, dendritic cells, balance of the immune response
Glutathione	Antioxidant protection of cells, detoxification, support of immune cells
KPV	Modulation of inflammatory processes (NF-κB pathway)

The box brings them together for researchers interested in a measured approach to body-weight change — with support for the body's defensive systems.

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7. Value in this box

	Value
Bought separately	24 200 ₽
Box price	20 600 ₽
Discount	3 600 ₽
BAC Water included free (4 × 500 ₽)	2 000 ₽
Total value	5 600 ₽ (23%)

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8. References

[1] Jastreboff A.M. et al. Triple-hormone-receptor agonist retatrutide for obesity — a phase 2 trial. N Engl J Med. 2023;389(6):514–526. PMID: 37366315

[2] Romani L. et al. Thymosin alpha1: an endogenous regulator of inflammation, immunity, and tolerance. Ann N Y Acad Sci. 2012;1270:32–36. PMID: 23050814

[3] Garaci E. et al. Thymosin alpha 1 in the treatment of cancer: from basic research to clinical application. Int J Immunopharmacol. 2000;22(12):1067–1076. PMID: 11137614

[4] Forman H.J. et al. Glutathione: overview of its protective roles, measurement, and biosynthesis. Mol Aspects Med. 2009;30(1–2):1–12. PMID: 18796312

[5] Kannengiesser K. et al. Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease. Inflamm Bowel Dis. 2008;14(3):324–331. PMID: 18092346

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For laboratory and research use only.